CANABINOIDES SINTÉTICOS

Abstract

Synthetic cannabinoids are laboratory-developed compounds, generally based on the structure of natural cannabinoids found in the cannabis plant. Their goal is to enhance therapeutic effects, reduce psychoactive effects, and expand knowledge about the endocannabinoid system. The main derivatives include hexahydrocannabinol (HHC), obtained by hydrogenation of THC and associated with psychotropic effects and antitumor activity; Δ8-THC, an isomer of Δ9-THC, which has a lower affinity for CB1 receptors and, therefore, milder effects; and THC-O-Acetate, produced by acetylation, resulting in a compound with more potent psychoactive effects. These analogs can be obtained through processes such as isomerization, hydrogenation, and acetylation, also involving additional steps for purification and isolation of the product. Although they have scientific and pharmacological relevance, the search for such compounds has given rise to recreational substances of abuse, such as Spice and K9, which reinforces the importance of control and responsible research.

Keywords: Synthetic cannabinoids; THC; K9; Spice; HHC.