CANNABINOID THERAPY: ACTION MECHANISMS IN THE CONTROL OF CHRONIC OROFACIAL PAIN

Authors

  • Gelson Nycollas Alcântara Dias Faculdade de Odontologia da Universidade Federal de Juiz de Fora
  • Vitor Knop Detoni Faculdade de Odontologia da Universidade Federal de Juiz de Fora
  • Ana Luisa Rocha Floriano Faculdade de Odontologia da Universidade Federal de Juiz de Fora
  • Lúbia Cerqueira Costa Faculdade de Odontologia da Universidade Federal de Juiz de Fora
  • Josemar Parreira Guimarães Faculdade de Odontologia da Universidade Federal de Juiz de Fora

DOI:

https://doi.org/10.58731/2965-0771.2024.39

Keywords:

Cannabis; Pharmacology; Facial Pain.

Abstract

ABSTRACT: Introduction: The hallucinogenic and relaxing effects of the Cannabis sativa plant have drawn attention to the possibilities of therapeutic application for centuries. Currently, in the national territory, the National Health Surveillance Agency regulates the plant for medicinal purposes making the compound viable as an emerging alternative in treating various clinical conditions, including Orofacial Pain. Methodology: A literature review was carried out from 2018 to 2023, in the databases PUBMED/MEDLINE, Periódico CAPES, Scielo, and Google Scholar, using the descriptors "Cannabis", "Pharmacology" and “Facial Pain". 42 scientific studies were identified, in which, through the application of inclusion and exclusion criteria, 23 were chosen to integrate the sampling of this research. Discussion: Therefore, as emerging perspectives,  the contribution includes scientific data concerning the endocannabinoid system, pharmacological nuances, therapeutic efficacy, applicability in Dentistry, and the use of medicinal cannabis in the context of orofacial pain. Thus, a reduction in chronic Orofacial Pain associated with Temporomandibular Disorders was observed, in addition to the reduction of masticatory muscle activity, contributing to improving the patient's quality of life. Transdermal application has proven to be more efficient and minimize adverse reactions. Conclusion: Based on the literature review, it can be concluded that additional studies are required in this field. Cannabinoid therapy presents itself as a potential therapeutic alternative for addressing orofacial pain and temporomandibular disorders.

Author Biographies

Gelson Nycollas Alcântara Dias, Faculdade de Odontologia da Universidade Federal de Juiz de Fora

Graduando em Odontologia pela Faculdade de Odontologia da Universidade Federal de Juiz de Fora

Vitor Knop Detoni, Faculdade de Odontologia da Universidade Federal de Juiz de Fora

Graduando em Odontologia pela Faculdade de Odontologia da Universidade Federal de Juiz de Fora

Ana Luisa Rocha Floriano, Faculdade de Odontologia da Universidade Federal de Juiz de Fora

Graduanda em Odontologia pela Faculdade de Odontologia da Universidade Federal de Juiz de Fora

Lúbia Cerqueira Costa, Faculdade de Odontologia da Universidade Federal de Juiz de Fora

Mestranda em Odontologia pela Faculdade de Odontologia da Universidade Federal de Juiz de Fora

Josemar Parreira Guimarães, Faculdade de Odontologia da Universidade Federal de Juiz de Fora

Mestre e Doutor em Odontologia, Docente Titular da Faculdade de Odontologia da Universidade Federal de Juiz de Fora

Published

2024-04-04

How to Cite

1.
Alcântara Dias GN, Knop Detoni V, Rocha Floriano AL, Cerqueira Costa L, Parreira Guimarães J. CANNABINOID THERAPY: ACTION MECHANISMS IN THE CONTROL OF CHRONIC OROFACIAL PAIN. RBCan [Internet]. 2024 Apr. 4 [cited 2024 Dec. 21];3(1). Available from: https://revistacannabis.med.br/sbec/article/view/39